In-vitro Toxicology Testing Market by Method, Technology, Application, and End User - Global Industry Analysis and Forecast to 2025

Report Code : HC06108

Toxicology testing is assessment of degree by which specific substance can damage living organisms. Toxicological studies are conducted to determine toxicity of final product such as pesticides, certain food additives, cosmetics and other chemical substances. Toxicological studies are necessary to provide basis for regulation of substances that humans and other living things may come in contact intentionally or unintentionally. Toxicological studies are conducted either in vitro or in vivo. In vitro toxicity testing is analysis of effect of toxic chemical substances on cultured mammalian cells or bacteria. During In vitro testing, fragments of living tissues are extracted and grown on artificial nutrient medium. These cultured cells are then exposed to substances and any changes in basic cell structure are noted to assess toxicology of substance. Cell, tissue and organ cultures are used in highly controlled toxicity tests which are often less expensive than traditional tests. These cell and tissue cultures provide a good screening mechanism and can reduce number of animals used for toxicology screening.

Murine Local Lymph Node Assay (LLNA), Corrositex, and Enzyme-linked immunosorbent assay (ELISA) are some of the frequently employed cell based assay for assessing toxic effect of substances. Murine local Lymph Node Assay (LLNA) is in vitro test used to detect allergic dermatitis due to continuous exposure of skin to chemicals. LLNA have ability to yield quick results as well as provide information about dose response unlike other traditional methods of cell assays. Cell lines assays are another common toxicology screening methods used owing to their ability to proliferate and differentiate into specific mature cells. Besides cell based assays, biochemical assays and in-silico based methods are also used to detect potential harmful effect of substances on human body.

Increasing opposition for use of animals in toxicological studies, increasing preference for in vitro toxicological testing and increasing R&D activities to develop advanced cell culture methods is expected to propel growth of the market. In addition, advancements in biotechnology and bioinformatics techniques for developing toxicology database for cell based analysis will drive growth of the market. Furthermore, increasing government focus towards biotech sector coupled with availability of advanced automated laboratories is expected to play significant role in growth of the market. However, absence of in vitro models to detect autoimmunity and immune stimulation is expected to slow down growth of the market.

Major players operating in this market include Catalent Inc., Charles River Laboratories, Cyprotex, Covance, Alere Inc., Quest Diagnostics, Bio-Rad, Thermo Fisher Scientific, Eurofins Scientific, Inc., and Agilent Technologies. These players are focusing on developing advanced software solutions in order to enhance methods used for toxicology profiling. In addition, these players are acquiring and collaborating with small clinical research organizations and laboratories to expand their market coverage. For instance in October 2016, Charles River Laboratories acquires Agilux Laboratories, Inc. to increase their bio analysis product portfolio. With this acquisition, Charles River Laboratories has expanded their proficiency to support varied research needs through preclinical development.

Innovations such as automated assays to screen large number of substances having similar properties to assess toxic effect of substances and rapid advancements in biotechnology and pharmaceutical industry will provide ample growth opportunities for market players. In silico studies performed via computer stimulation will open up new avenues for predicting toxicity of substances. Development of highly advanced cell based methods such as polymerase chain reaction that multiplies single copy of DNA to several order of magnitude generating millions of copies will revolutionize toxicology testing market providing lucrative growth opportunities in coming years.

The Global In-vitro Toxicology Testing Market Segmentation:

By Method

  • Biochemical Assay
  • In-Silico
  • Cellular Assay
  • Ex-vivo

By Technology

  • High Throughput Technology
  • OMICS Technology
  • Molecular imaging
  • Cell culture Technology

By Application

  • Dermal Toxicity
  • Ocular Toxicity
  • Endocrine Disruption
  • Systemic Toxicology

 By End User

  • Cosmetics & Household Products
  • Chemical Industry
  • Food Industry
  • Diagnostics
  • Pharmaceutical Industry

By Region

  • North America
  • U.S
  • Canada
  • Mexico
  • Europe
  • Germany
  • France
  • UK
  • Italy
  • Spain
  • Rest of Europe
  • Asia-Pacific
  • Japan
  • China
  • Australia
  • India
  • South Korea
  • Rest of Asia-Pacific
  • Rest of the World
  • Brazil
  • South Africa
  • Saudi Arabia
  • Turkey
  • United Arab Emirates
  • Others

Research Methodology

We use both primary as well as secondary research for our market surveys, estimates and for developing forecast. Our research process commence by analyzing the problem which enable us to design the scope for our research study. Our research process is uniquely designed with enough flexibility to adjust according to changing nature of products and markets, while retaining core element to ensure reliability and accuracy in research findings. We understand both macro and micro-economic factors to evaluate and forecast different market segments.

Data Mining

Data is extensively collected through various secondary sources such as annual reports, investor presentations, SEC filings, and other corporate publications. We also refer trade magazines, technical journals, paid databases such as Factiva and Bloomberg, industry trade journals, scientific journals, and social media data to understand market dynamics and industry trends. Further, we also conduct primary research to understand market drivers, restraints, opportunities, challenges, and competitive scenario to build our analysis.

Data Collection Matrix

Data Collection Matrix

Supply Side

Demand Side

Primary Data Sources

  • Manufacturers
  • Distributors & Wholesalers
  • GPOs
  • Physicians/Specialist
  • Healthcare Providers
  • Consumers

Secondary Data Sources

  • Annual Reports/SEC Filings/ Investor Presentations/ Press Releases
  • Government/Associations Publications
  • Case Studies
  • Reference Customers


Market Modeling and Forecasting

We use epidemiology and capital equipment-based models to forecast market size of different segments at country and regional level.

  • Epidemiology-based Forecasting Model: This method uses epidemiology data gathered through various publications and from physicians to estimate population of patients, flow of treatment of individual disease and therapies. The data collected through this method includes statics on incidence of disease, population suffering from disease, and treatment population. This method is used to understand:
  • Number of patients for particular device or medical procedure and
  • Repeated use of particular device depending on health and condition of patient
  • Capital-based Forecasting Model: This method of forecasting is based on number of replacements, installed-based and new sales of capital equipment used in various healthcare and diagnostic centers. These three parameters are calculated and forecast is developed. Installation base is calculated as average number of units per facility; while sales for particular year is calculated from number of new and replace units. Secondary data is collected through various supply chain intermediaries and opinion leaders to arrive at installation and sales rate. These techniques help our analysts in validating market and developed market estimates and forecast.

We do forecast on basis of several parameters such as market drivers, market opportunities, industry trends government regulations, raw materials supply and trade dynamics to ensure relevance of forecast with market scenario. With increasing need to granulized information, we used bottom-up methodology for forecasting where we evaluate each regional segment differently and combined all forecast to develop final market forecast.

Data Validation

We believe primary research is a very important tool in analyzing and forecasting different markets. In order to make sure accuracy of our findings, our team conducts primary interviews at every stage of research to gain deep insights into current business environment and future trends and key developments in market. This includes use of various methods such as telephonic interviews, focus groups, face to face interviews and questionnaires to validate our research from all aspects. We validate our data through primary research from key industry leaders such as CEO, product managers, marketing managers, suppliers, distributors, and consumers are frequently interviewed. These interviews provide valuable insights which help us to have better market understanding besides validating our estimates and forecast.

Data Triangulation

Industry Analysis

Qualitative Data

Quantitative Data (2017-2025)

  • Market Dynamics (Drivers, Restraints, and Challenges)
  • Industry Trend Analysis
  • Market Opportunities
  • Government Policies and Regulations, Patent Analysis, and Reimbursement Policies
  • Porter’s Five Forces and PESTLE Analysis
  • Key Developments and Competitive Landscape
  • Market Assessment and Forecast
  • Market Assessment and Forecast, By Product
  • Market Assessment and Forecast, By Technology
  • Market Assessment and Forecast, By Application
  • Market Assessment and Forecast, By End User
  • Market Assessment and Forecast, By Region/Country

License Type

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